Ionis Pharmaceuticals Inc
Ionis Pharmaceuticals Inc (IONS) Unusual Options Activity Today
IONS options volume power reached 42x on the previous trading day. The highest reading was on the $42.5 CALL expiring 2026-10-16.
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Checking IONS unusual options activity helps you spot when traders are making outsized bets on Ionis Pharmaceuticals Inc before the broader market catches on. Ionis Pharmaceuticals Inc's unusual options activity flags contracts trading at multiples of their average daily volume, often signaling that informed money is positioning ahead of a catalyst. Use our scanner to monitor IONS unusual options activity today and surface the prints that deserve a second look.
Unusual options flow typically refers to trades where volume vastly exceeds open interest at a given strike, or where total contract volume on a name spikes well above its norm. Watching IONS unusual options flow today can reveal large block trades, sweeps across exchanges, and aggressive directional bets. Tracking IONS unusual options volume across calls and puts helps you separate hedging activity from genuinely speculative positioning, and IONS unusual options flow data becomes especially valuable around earnings, product launches, and macro events.
Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; and WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of TTR amyloidosis; Olezarsen for patients with severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Tofersen to inhibit the production of superoxide dismutase 1.
In addition, the company develops medicines for metabolic diseases, infectious diseases, renal diseases, ophthalmic diseases, and cancer. It has a strategic collaboration with Biogen Inc.; and collaboration and license agreement with AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis AG, Roche, Janssen Biotech, Inc., and Flamingo Therapeutics, Inc. Ionis Pharmaceuticals, Inc. was founded in 1989 and is based in Carlsbad, California.
Catalysts rarely arrive without a footprint, and IONS unusual options activity is often where that footprint shows up first. Our scanner tracks Ionis Pharmaceuticals Inc's unusual options flow in real time, ranks prints by volume-to-open-interest, premium spent, and aggressor side, and separates real conviction from noise. Whether you're looking at IONS unusual options volume on the call side or chasing put sweeps, Ionis Pharmaceuticals Inc's unusual options flow today is one click away, so put it on your radar before the headlines hit.
| 45.00 | 2.10 | 3.70 | 2.90 | 62% | 18 | 181 | 9.94% |
| 50.00 | 0.60 | 1.00 | 0.80 | 56% | 39 | 2,061 | 1.89% |
| 57.50 | — | 0.40 | 0.40 | 81% | 4 | 1,699 | 0.24% |
| 60.00 | — | 0.10 | 0.10 | 68% | 5 | 2,374 | 0.21% |
| 55.00 | — | 0.40 | 0.40 | 69% | 3 | 1,942 | 0.15% |
| 42.50 | 0.25 | 1.00 | 0.63 | 50% | 13 | 570 | 2.28% |
| 50.00 | 4.30 | 6.70 | 5.50 | 76% | 11 | 884 | 1.24% |
| 45.00 | 0.55 | 1.45 | 1.00 | 37% | 2 | 853 | 0.23% |
| 52.50 | 4.80 | 8.60 | 6.70 | 45% | 1 | 3,322 | 0.03% |
| 35.00 | — | 2.15 | 2.15 | 180% | 0 | 4 | 0.00% |
As of September 29, 2026
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