Karyopharm Therapeutics Inc

KPTINASDAQ · USD
1.62USD0.00 (-6.36%)
142

Karyopharm Therapeutics Inc (KPTI) Options Open Interest

KPTI options open interest is 43,913 contracts. The 2-week average daily volume is 1,657 contracts across the chain.

Read more

Monitoring KPTI open interest helps you see where real money is positioned on Karyopharm Therapeutics Inc's options and which strikes are attracting the most commitment from traders. Karyopharm Therapeutics Inc's open interest reflects the total number of outstanding contracts that have not been closed or exercised, making it a powerful gauge of liquidity, conviction, and potential support and resistance zones. Use our scanner to monitor KPTI options open interest in real time and find the strikes that matter.

Open interest is distinct from volume: volume counts how many contracts are traded in a session, while open interest counts how many remain open at the end of the day. Rising KPTI options open interest alongside rising volume suggests new positions are being built, while falling open interest signals positions are being closed. Heavy open interest at specific strikes often acts as a magnet near expiration and can hint at where dealers and large traders expect Karyopharm Therapeutics Inc to settle.

Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases. The company discovers, develops, and commercializes novel and Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1. Its lead compound, include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma, in combination with dexamethasone for the treatment of adult patients with heavily pretreated multiple myeloma, and for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma.

The company has license agreement with Menarini Group to develop and commercialize NEXPOVIO for human oncology indications in Europe, including the United Kingdom; Latin America; and other countries. Its oral SINE compounds also designed to force nuclear accumulation in the levels of multiple tumor suppressor and growth regulatory proteins. The company was incorporated in 2008 and is headquartered in Newton, Massachusetts.

Pin risk into expiration, dealer positioning, liquidity checks for large orders — all of it starts with knowing where KPTI open interest is concentrated. Our scanner maps Karyopharm Therapeutics Inc's open interest across every strike and expiry, flags unusual buildups, and lets you drill into the contracts that institutional money is actually holding. Trade Karyopharm Therapeutics Inc's options open interest as the signal it is, not as an afterthought.

2026-10-16
Calls
2.500.050.250.15243%+0.324012,787
1.50—1.001.00709%+0.81366,857
1.000.350.850.6026%+1.0000582
2.00—1.001.00792%+0.7973185
5.00—0.100.10359%+0.186610
Puts
1.00—0.100.10266%-0.1397245
1.50—0.300.30246%-0.334365
0.50—0.050.05424%-0.047350
2.000.050.700.389%-1.000029
2.500.451.450.95185%-0.77580

As of September 25, 2026

Follow the money

Track KPTI open interest across every strike and expiration, identify where conviction is building, and trade with the positioning data on your side.

Start your 14-day free trial