Spero Therapeutics Inc

SPRONASDAQ · USD
1.13USD+0.01 (+0.45%)
912

Spero Therapeutics Inc (SPRO) Historical Volatility

SPRO 30-day historical volatility is 29%. This ranks in the 0th percentile of readings over the past year.

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Tracking SPRO historical volatility helps you see how much Spero Therapeutics Inc's stock price has actually moved over past periods, giving you a baseline to judge whether current option premiums are fair, cheap, or expensive. While implied volatility tells you what the market expects, Spero Therapeutics Inc's HV tells you what really happened. Use our scanner to monitor SPRO 30 day historical volatility alongside longer lookback windows and spot the moments when realized and implied diverge.

Historical volatility is the annualized standard deviation of an underlying's past returns, typically measured over rolling windows like 10, 20, 30, or 60 days. The SPRO 30 day historical volatility is one of the most widely watched readings because it balances responsiveness with stability. Comparing Spero Therapeutics Inc's HV to its implied volatility reveals the volatility risk premium — when IV sits well above HV, option sellers tend to have an edge; when HV runs hot relative to IV, buyers may be underpaying for movement.

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying, developing, and commercializing treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adults; SPR206, a direct acting IV-administered agent to treat MDR Gram-negative bacterial infections in the hospital; and SPR720, an oral antibiotic for the treatment of non-tuberculous mycobacterial pulmonary disease.

It has license agreement with Meiji Seika Pharma Co., Ltd. to support the development of tebipenem HBr; license agreement with Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries; collaboration agreement with Bill & Melinda Gates Medical Research Institute to develop SPR720 for the treatment of lung infections caused by Mycobacterium tuberculosis; and license agreement with Vertex Pharmaceuticals Incorporated for patents relating to SPR720, as well as SPR719, an active metabolite. The company was founded in 2013 and is headquartered in Cambridge, Massachusetts.

Sizing a long premium trade, modeling a covered call, or hunting volatility arbitrage all come back to one question: how much has the stock actually moved? Our scanner puts Spero Therapeutics Inc's historical volatility side-by-side with implied readings across every lookback window, so you can see exactly where SPRO HV is running hot, cold, or in line. Make the SPRO 30 day historical volatility — and every other window — work for your edge instead of against it.

IV vs HV
Implied Volatility (IV) vs Historical Volatility (HV) over the past month.

As of September 17, 2026

IV - HV Difference
Difference between IV and HV over time. Positive values indicate IV > HV.

As of September 17, 2026

See how volatility has moved over time

Track SPRO historical volatility, spot where IV and realized volatility diverge, and find options that are priced in your favor right now.

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