Spero Therapeutics Inc
Spero Therapeutics Inc (SPRO) Options Open Interest
SPRO options open interest is 7,742 contracts. The 2-week average daily volume is 106 contracts across the chain.
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Monitoring SPRO open interest helps you see where real money is positioned on Spero Therapeutics Inc's options and which strikes are attracting the most commitment from traders. Spero Therapeutics Inc's open interest reflects the total number of outstanding contracts that have not been closed or exercised, making it a powerful gauge of liquidity, conviction, and potential support and resistance zones. Use our scanner to monitor SPRO options open interest in real time and find the strikes that matter.
Open interest is distinct from volume: volume counts how many contracts are traded in a session, while open interest counts how many remain open at the end of the day. Rising SPRO options open interest alongside rising volume suggests new positions are being built, while falling open interest signals positions are being closed. Heavy open interest at specific strikes often acts as a magnet near expiration and can hint at where dealers and large traders expect Spero Therapeutics Inc to settle.
Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying, developing, and commercializing treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adults; SPR206, a direct acting IV-administered agent to treat MDR Gram-negative bacterial infections in the hospital; and SPR720, an oral antibiotic for the treatment of non-tuberculous mycobacterial pulmonary disease.
It has license agreement with Meiji Seika Pharma Co., Ltd. to support the development of tebipenem HBr; license agreement with Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries; collaboration agreement with Bill & Melinda Gates Medical Research Institute to develop SPR720 for the treatment of lung infections caused by Mycobacterium tuberculosis; and license agreement with Vertex Pharmaceuticals Incorporated for patents relating to SPR720, as well as SPR719, an active metabolite. The company was founded in 2013 and is headquartered in Cambridge, Massachusetts.
Pin risk into expiration, dealer positioning, liquidity checks for large orders — all of it starts with knowing where SPRO open interest is concentrated. Our scanner maps Spero Therapeutics Inc's open interest across every strike and expiry, flags unusual buildups, and lets you drill into the contracts that institutional money is actually holding. Trade Spero Therapeutics Inc's options open interest as the signal it is, not as an afterthought.
| 5.00 | — | 0.05 | 0.05 | 359% | +0.1327 | 1,816 |
| 2.50 | — | 0.05 | 0.05 | 239% | +0.1708 | 1,181 |
| 7.50 | — | 0.20 | 0.20 | 594% | +0.3283 | 177 |
| 1.50 | — | 0.05 | 0.05 | 128% | +0.2570 | 100 |
| 2.00 | — | 0.05 | 0.05 | 194% | +0.1953 | 5 |
| 2.50 | 0.45 | 1.45 | 0.95 | 38% | -1.0000 | 924 |
| 1.00 | — | 0.15 | 0.15 | 195% | -0.3025 | 20 |
| 0.50 | — | 0.05 | 0.05 | 320% | -0.0793 | 1 |
| 1.50 | 0.05 | 1.05 | 0.55 | 257% | -0.5287 | 0 |
| 2.00 | 0.40 | 1.40 | 0.90 | 188% | -0.8160 | 0 |
As of September 21, 2026
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