Denali Therapeutics Inc

DNLINASDAQ · USD
18.82USD-0.11 (-0.59%)
127

Denali Therapeutics Inc (DNLI) Options Open Interest

DNLI options open interest is 12,192 contracts. The 2-week average daily volume is 774 contracts across the chain.

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Monitoring DNLI open interest helps you see where real money is positioned on Denali Therapeutics Inc's options and which strikes are attracting the most commitment from traders. Denali Therapeutics Inc's open interest reflects the total number of outstanding contracts that have not been closed or exercised, making it a powerful gauge of liquidity, conviction, and potential support and resistance zones. Use our scanner to monitor DNLI options open interest in real time and find the strikes that matter.

Open interest is distinct from volume: volume counts how many contracts are traded in a session, while open interest counts how many remain open at the end of the day. Rising DNLI options open interest alongside rising volume suggests new positions are being built, while falling open interest signals positions are being closed. Heavy open interest at specific strikes often acts as a magnet near expiration and can hint at where dealers and large traders expect Denali Therapeutics Inc to settle.

Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutic candidates for neurodegenerative diseases in the United States. It offers leucine-rich repeat kinase 2 (LRRK2) inhibitor product candidate, including BIIB122/DNL151, a small molecule inhibitor, which is in phase I and phase Ib clinical trials for the treatment of Parkinson's disease. The company also develops DNL310 that is in Phase I/II clinical trials for the treatment of hunter syndrome; DNL343, which is in phase 1 clinical trial the treatment of amyotrophic lateral sclerosis (ALS); AR443820/DNL788 completed a phase I clinical trial for the treatment of ALS, multiple sclerosis (MS), and Alzheimer's disease; and SAR443122/DNL758, which is in phase II clinical trial for the treatment of cutaneous lupus erythematosus.

It has collaboration agreement with Takeda Pharmaceutical Company, Genentech, Inc., Sanofi, F-star Gamma Limited, F-star Biotechnologische Forschungs-Und Entwicklungsges M.B.H, F-star Biotechnology Limited, SIRION Biotech GmbH, Genzyme Corporation, Harvard University, the Michael J. Fox Foundation, and Centogene; and a research and option agreement with Secarna Pharmaceuticals GmbH & Co. KG. to develop antisense therapies in the field of neurodegenerative diseases. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.

Pin risk into expiration, dealer positioning, liquidity checks for large orders — all of it starts with knowing where DNLI open interest is concentrated. Our scanner maps Denali Therapeutics Inc's open interest across every strike and expiry, flags unusual buildups, and lets you drill into the contracts that institutional money is actually holding. Trade Denali Therapeutics Inc's options open interest as the signal it is, not as an afterthought.

2026-11-20
Calls
25.00—0.350.3585%+0.1594250
17.500.904.302.6084%+0.6769140
20.001.152.001.5891%+0.474559
15.002.556.004.2878%+0.875620
12.504.808.506.65105%+0.937110
Puts
25.004.408.206.3082%-0.850120
20.000.154.202.1872%-0.555812
22.502.306.104.2083%-0.71919
17.50—2.002.00128%-0.34224
12.50—2.452.45290%-0.17930

As of October 20, 2026

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Track DNLI open interest across every strike and expiration, identify where conviction is building, and trade with the positioning data on your side.

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