Denali Therapeutics Inc

DNLINASDAQ · USD
19.72USD0.00 (-2.04%)
139

Denali Therapeutics Inc (DNLI) Options Open Interest

DNLI options open interest is 13,819 contracts. The 2-week average daily volume is 1,166 contracts across the chain.

Read more

Monitoring DNLI open interest helps you see where real money is positioned on Denali Therapeutics Inc's options and which strikes are attracting the most commitment from traders. Denali Therapeutics Inc's open interest reflects the total number of outstanding contracts that have not been closed or exercised, making it a powerful gauge of liquidity, conviction, and potential support and resistance zones. Use our scanner to monitor DNLI options open interest in real time and find the strikes that matter.

Open interest is distinct from volume: volume counts how many contracts are traded in a session, while open interest counts how many remain open at the end of the day. Rising DNLI options open interest alongside rising volume suggests new positions are being built, while falling open interest signals positions are being closed. Heavy open interest at specific strikes often acts as a magnet near expiration and can hint at where dealers and large traders expect Denali Therapeutics Inc to settle.

Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutic candidates for neurodegenerative diseases in the United States. It offers leucine-rich repeat kinase 2 (LRRK2) inhibitor product candidate, including BIIB122/DNL151, a small molecule inhibitor, which is in phase I and phase Ib clinical trials for the treatment of Parkinson's disease. The company also develops DNL310 that is in Phase I/II clinical trials for the treatment of hunter syndrome; DNL343, which is in phase 1 clinical trial the treatment of amyotrophic lateral sclerosis (ALS); AR443820/DNL788 completed a phase I clinical trial for the treatment of ALS, multiple sclerosis (MS), and Alzheimer's disease; and SAR443122/DNL758, which is in phase II clinical trial for the treatment of cutaneous lupus erythematosus.

It has collaboration agreement with Takeda Pharmaceutical Company, Genentech, Inc., Sanofi, F-star Gamma Limited, F-star Biotechnologische Forschungs-Und Entwicklungsges M.B.H, F-star Biotechnology Limited, SIRION Biotech GmbH, Genzyme Corporation, Harvard University, the Michael J. Fox Foundation, and Centogene; and a research and option agreement with Secarna Pharmaceuticals GmbH & Co. KG. to develop antisense therapies in the field of neurodegenerative diseases. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.

Pin risk into expiration, dealer positioning, liquidity checks for large orders — all of it starts with knowing where DNLI open interest is concentrated. Our scanner maps Denali Therapeutics Inc's open interest across every strike and expiry, flags unusual buildups, and lets you drill into the contracts that institutional money is actually holding. Trade Denali Therapeutics Inc's options open interest as the signal it is, not as an afterthought.

2026-10-16
Calls
22.502.502.50163%+0.47281
30.002.152.15225%+0.35501
12.505.309.507.40113%+0.95000
15.003.107.005.0591%+0.89160
17.500.754.502.6357%+0.80660
Puts
17.502.552.55178%-0.31043
15.002.252.25228%-0.22501
12.502.202.20299%-0.16600
20.001.203.402.30102%-0.46080
22.501.154.903.0353%-0.79310

As of September 18, 2026

Follow the money

Track DNLI open interest across every strike and expiration, identify where conviction is building, and trade with the positioning data on your side.

Start your 14-day free trial