Spyre Therapeutics Inc
Spyre Therapeutics Inc (SYRE) Historical Volatility
SYRE 30-day historical volatility is 49%. This ranks in the 7th percentile of readings over the past year.
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Tracking SYRE historical volatility helps you see how much Spyre Therapeutics Inc's stock price has actually moved over past periods, giving you a baseline to judge whether current option premiums are fair, cheap, or expensive. While implied volatility tells you what the market expects, Spyre Therapeutics Inc's HV tells you what really happened. Use our scanner to monitor SYRE 30 day historical volatility alongside longer lookback windows and spot the moments when realized and implied diverge.
Historical volatility is the annualized standard deviation of an underlying's past returns, typically measured over rolling windows like 10, 20, 30, or 60 days. The SYRE 30 day historical volatility is one of the most widely watched readings because it balances responsiveness with stability. Comparing Spyre Therapeutics Inc's HV to its implied volatility reveals the volatility risk premium — when IV sits well above HV, option sellers tend to have an edge; when HV runs hot relative to IV, buyers may be underpaying for movement.
Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies.
In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.
Sizing a long premium trade, modeling a covered call, or hunting volatility arbitrage all come back to one question: how much has the stock actually moved? Our scanner puts Spyre Therapeutics Inc's historical volatility side-by-side with implied readings across every lookback window, so you can see exactly where SYRE HV is running hot, cold, or in line. Make the SYRE 30 day historical volatility — and every other window — work for your edge instead of against it.
As of September 28, 2026
As of September 28, 2026
See how volatility has moved over time
Track SYRE historical volatility, spot where IV and realized volatility diverge, and find options that are priced in your favor right now.
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