Spyre Therapeutics Inc
Spyre Therapeutics Inc (SYRE) Wheel Strategy
SYRE wheel strategy scan found 25 cash-secured put setups on the previous trading day. Probability of expiring worthless is above 50%. Annualized returns reach up to 93.7%.
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Running a SYRE wheel strategy lets you generate consistent premium income on Spyre Therapeutics Inc while setting your own entry and exit prices on the underlying. Spyre Therapeutics Inc's wheel combines cash-secured puts and covered calls into a repeatable cycle: sell puts at strikes where you'd be happy to own SYRE, and if assigned, sell calls at strikes where you'd be happy to sell. Use our scanner to find the best SYRE wheel strategy setups in real time.
The wheel works best on liquid, high-quality names with stable fundamentals and active options markets — exactly the profile many large-cap leaders fit. The mechanics are simple: sell a cash-secured put on SYRE, collect premium, and either keep the premium if it expires worthless or take assignment at a discount to current price. Once assigned, sell covered calls against the shares to keep collecting premium until they're called away. Choosing the right strikes, expirations, and IV environment is what separates a profitable SYRE wheel from a losing one.
Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies.
In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.
The difference between a wheel that compounds and one that bleeds comes down to strike selection, IV timing, and discipline on assignment. Our scanner handles the heavy lifting: it ranks every leg of the SYRE wheel strategy by delta, premium yield, IV rank, and days to expiration, so you can deploy capital where the math works. Build your SYRE wheel strategy on data, not gut feel — and let the options wheel do what it does best: pay you to wait.
| Oct 16, 2026 | 85.00 | $3.30 | $4.80 | -0.40 | 22 | 2% | 54.7% | 93.7% | 155 |
| Nov 20, 2026 | 85.00 | $6.60 | $8.30 | -0.40 | 57 | 2% | 50.8% | 62.5% | 1 |
| Nov 20, 2026 | 80.00 | $5.20 | $6.55 | -0.32 | 57 | 2% | 61.2% | 52.4% | 12 |
| Oct 16, 2026 | 80.00 | $0.50 | $2.25 | -0.26 | 22 | 2% | 70.8% | 46.7% | 30 |
| Dec 18, 2026 | 80.00 | $5.20 | $7.25 | -0.33 | 85 | 2% | 57.8% | 38.9% | 0 |
| Jan 15, 2027 | 80.00 | $6.00 | $8.25 | -0.33 | 113 | 2% | 55.6% | 33.3% | 0 |
| Nov 20, 2026 | 75.00 | $1.50 | $3.75 | -0.24 | 57 | 2% | 71.5% | 32.0% | 11 |
| Mar 19, 2027 | 80.00 | $9.60 | $11.40 | -0.32 | 176 | 2% | 52.3% | 29.6% | 0 |
| Dec 18, 2026 | 75.00 | $2.55 | $4.98 | -0.25 | 85 | 2% | 66.6% | 28.5% | 0 |
| Nov 20, 2026 | 70.00 | $1.05 | $2.98 | -0.18 | 57 | 2% | 80.8% | 27.2% | 2 |
As of September 28, 2026
Run the Wheel on SYRE With Confidence
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